Hutchison's investments in energy and infrastructure are mainly in Asia, Australia, North America and the United Kingdom.

In April 2004, Cheung Kong Infrastructure Holdings Limited (CKI) announced its first venture into water assets in the UK by acquiring Cambridge Water in South Cambridgeshire. Cambridge Water possesses an integrated distribution system that includes seven service reservoirs, 10 water towers and 2,200 kilometres of water mains, supplying a population of approximately 298,000 in an area that spans more than 1,173 square kilometres.

In June 2005, HWL, CKI and Hongkong Electric Holdings Limited (HK Electric) ompleted acquisition of Northern Gas Networks Limited that owns the North of England Gas Distribution Network (NEG) in the United Kingdom. NEG is one of the eight major gas distribution networks in the UK. Its network extends south from the Scottish border to South Yorkshire, containing a mixture of large cities (Newcastle, Middlesborough, Leeds and Bradford) and a significant rural area including North Yorkshire and Cumbria. It comprises approximately 37,000 kilometres of distribution gas mains, serving a total population of 6.7 million. In December 2007, CKI acquired a 4.75 per cent interest in Southern Water Group, a regulated water and sewage company in the UK. In May 2010, CKI and HK Electric acquired 50 per cent interests in Seabank Power Limited, which owns and operates a 1,140MW gas-fired combined cycle power plant near Bristol in the United Kingdom.

In May 2006, Hutchison China MediTech Limited (Chi-Med), the holding company of a pharmaceutical and healthcare group based primarily in Mainland China, is listed on the Alternative Investment Market of The London Stock Exchange Plc (stock code: HCM). Chi-Med focuses on researching, developing, manufacturing and selling pharmaceuticals, health supplements and other consumer health and personal care products derived from Traditional Chinese Medicine (TCM) and botanical ingredients. Chi-med's retail brand, Sen opened its first store in December 2002 and now has a presence in the UK, France, and Hong Kong.

Hutchison's finance and investment income is derived from a substantial pool of cash, managed funds and listed investments.